HRCR Rare Diseases Article Collection
Cardiac sarcoidosis involving the papillary muscle: A case reportSarcoidosis is a granulomatous multisystem disease that is thought to arise from a dysregulated immunological response. A total of 25% of those suffering from sarcoidosis have cardiac involvement on postmortem analysis, but it is clinically apparent in only 5%.1 Isolated cardiac sarcoidosis (CS) has also been described.2 It may manifest as conduction system dysfunction, ventricular arrhythmias, congestive cardiac failure, or sudden cardiac death.3 CS has a predilection for the ventricular myocardium and its clinical presentation may vary from no symptoms to sudden cardiac death.
A case of cardiac sarcoidosis with concurrent myocardial ischemiaSarcoidosis is a rare multisystem disease of unknown etiology affecting 10–40 in 100,000 population, characterized by granulomatous inflammation.1 It has a diverse set of presentations ranging from diffuse to localized disease and can have either acute or chronic clinical course with multiple organ involvement.1 Classically, lungs are the most commonly affected organ, but systemic, dermatologic, and cardiac involvement also occur. Specifically, 20%–30% of sarcoidosis patients have been observed to have cardiac involvement in an autopsy1; however, only about 5% have a symptomatic presentation with cardiac disease.